Program and Videorecordings

Session 1: Friday, October 9 (9-11.30am Pacific / noon-2.30pm Eastern / 6-8.30pm Paris)

OPENING KEYNOTE

Germ Cell Exposures and Heritable Effects: Is Our Regulatory Paradigm Failing to Protect Future Generations?

• David DeMarini, PhD, US Environmental Protection Agency (ret)

View the recording View the slides (PDF)


MECHANISMS OF INTERGENERATIONAL INHERITANCE, PART 1
Co-chairs: Wei Yan, Isabelle Mansuy, Roxane Verdikt

Integration of Epigenetic Mechanisms in the Germline and Embryo in Epigenetic Transgenerational Inheritance
• Michael Skinner, PhD, Washington State University (Recording not available at this time)

Mechanisms of Transgenerational Inheritance of Obesity Epiphenotypes
• Victor Corces, PhD, Emory University View the recording

Blood Factors Are Vectors of Communication Between Exposure and the Germline
• Isabelle Mansuy, PhD, University and ETH Zürich View the recording

Sperm-borne tsRNAs Are Required for Maternal Transmission of Epimutations
• Wei Yan, MD, PhD, UCLA (Recording not available at this time)

Session 2: Wednesday, October 21 (9-11.30am Pacific / noon-2.30pm Eastern / 6-8.30pm Paris)

MECHANISMS OF INTERGENERATIONAL INHERITANCE, PART 2
Co-chairs: Wei Yan, Isabelle Mansuy, Roxane Verdikt

Transgenerational Epigenetic Markers of Autism
• Minoo Rassoulzadegan, PhD, Erciyes University Medical Faculty, Medical Genetics Department, Kayseri, Turkey. Université Côte d’Azur, CNRS, Inserm, France (Recording not available at this time)

Assisted Reproductive Technologies: Epigenetic Impacts and Long-term Outcomes
• Marisa Bartolomei, PhD, University of Pennsylvania View the recording

The Legacy of Paternal Exposure to Toxicants: More than Just Gene Mutations
• Francesco Marchetti, PhD, Health Canada View the recording

Multiparametric Analysis of the Spermatogonial Stem Cell Epigenome
• John R. McCarrey, PhD, University of Texas at San Antonio View the recording

Epigenetic Variation in Human Sperm Under Lifestyle Influences
• Romain Barrès, PhD, University of Copenhagen (Recording not available at this time)

Session 3: Friday, November 6 (9-11.30am Pacific / noon-2pm Eastern / 6-8.30pm Paris)

OPENING TALK

Evidence for Germline Non-genetic Inheritance of Human Phenotypes and Diseases
• Matthew Smith-Raska, MD, PhD, Weill Cornell Medical View the recording

SHORT TALKS
Chairs: Mathia Colwell and Patrick Allard

Paternal Drug Exposure Reveals Previously Unconsidered Class of Sperm RNA as Novel Candidate in RNA-mediated Inheritance
• Katharina Gapp, PhD, Center for Neuroscience Zürich ETHZ and Uni Zürich (Recording not available at this time)

Transgenerational Transmission of Behavioral Phenotypes in a Mouse Model of Paternal Saccharin and Nicotine Exposure
• Dierdre McCarthy, Florida State University, Tallahassee, FL View the recording

Developmental Cannabidiol Exposure Increases Anxiety and Modifies Genome-wide Brain DNA Methylation in Adult Female Mice
• Nicole Wanner, DVM, University of Minnesota View the recording

Developmental TCDD Exposure Results in Multigenerational Histological, Transcriptomic, and Methylomic Abnormalities in Male Zebrafish Gonads
• Danielle Meyer, Wayne State University View the recording

Caenorhabditis elegans SET1/COMPASS Maintains Germline Identity by Preventing Transcriptional Deregulation Across Generations
• Valerie Robert, LBMC, ENS Lyon View the recording

Transgenerational Transmission of Anxiety and Working Memory Deficit Following Paternal Aspartame Exposure
• Sara Jones, Florida State University View the recording

The National Birth Defect Registry, a Novel Approach to Identify Birth Defect Clusters for Case Control Studies
• Betty Mekdeci, National Birth Defect Registry View the slides View the intro video

Session 4: Friday, November 20 (9am-noon Pacific / noon-3pm Eastern / 6-9pm Paris)

HERITABLE IMPACTS OF TOBACCO, CANNABIS AND RELATED PRODUCTS
Co-chairs: Rose Schrott and Jordan Buck

Human studies:

Smoking in Pregnancy by the Grandmother and Associated Outcomes in the Grandchild
• Jean Golding, PhD, University of Bristol, UK View the recording

Grandmaternal smoking during pregnancy is associated with differential DNA methylation in their grandchildren
• Sarah Watkins, PhD, University of Bristol, UK View the recording

Packing a Punch: Preconception Paternal Priming of Potential Prenatal and Postnatal Problems from Partaking in Pot
• Susan Murphy, PhD, Duke University View the recording

Parental Smoking and Occupational Exposures as Related to Offspring Asthma
• Cecilie Svanes, MD, PhD, University of Bergen, Norway View the recording

Smoking During Pregnancy and RIsk of Attention-Deficit/Hyperactivity Disorder in the Third Generation
• Gyeyoon Yim, ScD, Harvard T.H. Chan School of Public Health View the recording

Mammalian experiments:

Transgenerational Transmission of the Effects of Nicotine Exposure
• Pradeep Bhide, PhD, Florida State University View the recording

Oxidative Stress Underlies Heritable Impacts of Cigarette Smoking
• Patrick J. Murphy, Ph.D, University of Rochester Medical Center View the recording

Developmental Nicotine Exposure Elicits Multigenerational Transmission of Neurodevelopmental Disorder-like Phenotypes in Adolescent Mice
• Jordan Buck, PhD, University of Colorado View the recording

Cannabis Smoke Extract Impacts the Rat Sperm Epigenome
• Rose Schrott, PhD candidate, Duke University View the recording

Session 5: Friday, December 4 (9am-1.00 Pacific / noon-4.00pm Eastern / 6-10.00pm Paris)

HERITABLE IMPACTS OF ENDOCRINE DISRUPTING COMPOUNDS
Chair: Matthew Smith-Raska, 1 hour, 45 minutes

Sex Differences in Inter- and Transgenerational Effects of EDCs on the Developing Brain
• Andrea Gore, PhD, University of Texas, Austin View the recording

Intergenerational Effects of Thyroid Hormone
• Arturo Hernandez, PhD, Maine Medical Center Research Institute, MaineHealth View the recording

Comparative Actions of Environmental Toxicants in Epigenetic Transgenerational Inheritance of Pathology, and Use of Epimutation Biomarkers of Exposure and Disease
• Michael Skinner, PhD, Washington State University (Recording not available at this time)

Physiologically Relevant Bisphenol A Levels Alter the Developmental Trajectory of an In Vitro Model of Mouse Primordial Germ Cells
• Steen Ooi, PhD, UCLA View the recording

Brief break

HERITABLE IMPACTS OF DIETHYLSTILBESTROL (DES) This session will begin at approximately 2pm ET
Chair: Suzanne Robotti, 2 hours

Results and Signals from the Ongoing NCI Multi-Generational DES Follow-up Study 
• Linda Titus, PhD, Dartmouth Geisel School of Medicine View the recording

DES Exposure During Pregnancy and Third-Generation Neurodevelopmental Deficits
• Marianthi Kioumourtzoglou, ScD, Columbia University View the recording

To be followed by interactive discussion of DES grandchild effects, including:

• Subhrangsu S. Mandal, PhD, University of Texas at Arlington View the recording
• Kari Christianson, MedShadow, and former research director, DES Action USA View the recording
• Scott Kerlin, PhD, independent researcher View the recording
• Michel Tournaire, MD

Session 6: Friday, December 11 (9am-11.30am Pacific / noon-2.30pm Eastern / 6-8.30pm Paris)

HERITABLE IMPACTS OF GENERAL ANESTHESIA
Chair: Jill Escher

Short talk: Associations of parental birth characteristics with autism spectrum disorder (ASD) risk in their offspring: A population-based multigenerational cohort study in Denmark
• Jingyuan Xiao, PhD student, Yale School of Public Health View the recording

Part 1: Developmental Toxicity of General Anesthetic Gases
Part 2: Germline Exposure to Sevoflurane Results in Dysregulation of Brain-Related Genes in Offspring
• Vesna Jevtovic-Todorovic, MD, PhD, MBA, University of Colorado View the recording

Intergenerational Effects of Sevoflurane at Molecular and Behavioral Levels
• Anatoly Martynyuk, PhD, University of Florida (Recording not available at this time)

General Anesthetics Induce Epigenetic Alterations in Germ Cells that Result in Autism-like Behaviors
• Hsiao-Lin V. Wang, PhD, Emory University View the recording

Effects of In Utero Halothane Anesthesia Exposure on Germ Cell Methylation and Cognitive Behavior
• Melissa Pepling, PhD, Syracuse University View the recording

CLOSING TALK:

The Vulnerability of the Germline: Moral Responsibilities Towards Present and Future Generations
• Anne Le Goff, PhD, University of California, Los Angeles, Institute for Society and Genetics and EpiCenter View the recording